Targeting the tumor-stromal-immune cell axis
نویسندگان
چکیده
منابع مشابه
Targeting the tumor-stromal-immune cell axis
Cancer associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a critical role in tumor progression. We and others have demonstrated that stromal fibroblasts can transform adjacent epithelial cancer cells in vivo. Cancer cells and stromal cells interact through physical contact, mediated by soluble factors, insoluble extracellular matrices (ECMs) or extracellular vesicles (EVs) i...
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Objective(s):miR-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (GCT) of bone remains poorly understood. The current study aimed to investigate the potential role and mechanism of miR-125b in GCT. Materials and Methods:Expression levels of miR-125b in GCT tissues were determined using RT-PCR. The cell proliferation was surveyed by direct cell coun...
متن کاملmir-125b inhibits stromal cell proliferation in giant cell tumor of bone by targeting parathyroid hormone 1 receptor
objective(s):mir-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (gct) of bone remains poorly understood. the current study aimed to investigate the potential role and mechanism of mir-125b in gct. materials and methods:expression levels of mir-125b in gct tissues were determined using rt-pcr. the cell proliferation was surveyed by direct cell coun...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.190